Premium
Transient receptor potential vanilloid 4 (TRPV4)‐dependent calcium influx and ATP release in mouse oesophageal keratinocytes
Author(s) -
Mihara Hiroshi,
Boudaka Ammar,
Sugiyama Toshiro,
Moriyama Yoshinori,
Tominaga Makoto
Publication year - 2011
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.2011.207829
Subject(s) - trpv4 , transient receptor potential channel , chemistry , stimulation , calcium , trpv1 , microbiology and biotechnology , trpv , biophysics , receptor , endocrinology , medicine , biochemistry , biology , organic chemistry
Non‐technical summary In the oesophagus the ion channel TRPV4 senses multiple stimuli, including heat and mechanical stimulation. TRPV4 activation causes ATP release from oesophageal cells, which could be important in oesophageal disease mechanisms.