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Adenosine A2A receptor induces protein kinase A‐dependent functional modulation of human α3β4 nicotinic receptor
Author(s) -
Di Angelantonio Silvia,
Piccioni Alessio,
Moriconi Claudia,
Trettel Flavia,
Cristalli Gloria,
Grassi Francesca,
Limatola Cristina
Publication year - 2011
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.2011.207282
Subject(s) - adenosine , adenosine a2b receptor , acetylcholine receptor , nicotinic agonist , nicotine , adenosine receptor , alpha 4 beta 2 nicotinic receptor , nicotinic acetylcholine receptor , chemistry , adenosine a2a receptor , microbiology and biotechnology , receptor , adenosine a3 receptor , purinergic signalling , ion channel , biochemistry , biology , neuroscience , agonist
Non‐technical summary In many brain regions, adenosine regulates the function of the nicotinic acetylcholine receptor–channel, which allows the movement of ions across neuronal membrane if nicotine or acetylcholine is present. In this work we use a very controlled experimental system to study the details of adenosine action. We show that adenosine enhances the function of the receptor–channel when it is repeatedly stimulated. The intracellular signalling molecule protein kinase A mediates the effects of adenosine on the nicotinic receptor–channel. Our results contribute to understanding the function of receptor proteins involved in the normal function of the brain, but also in pathologies such as nicotine addiction.