Premium
Striated muscle activator of Rho signalling (STARS) is a PGC‐1α/oestrogen‐related receptor‐α target gene and is upregulated in human skeletal muscle after endurance exercise
Author(s) -
Wallace Marita A.,
Hock M. Benjamin,
Hazen Bethany C.,
Kralli Anastasia,
Snow Rod J.,
Russell Aaron P.
Publication year - 2011
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.2011.205468
Subject(s) - skeletal muscle , endocrinology , activator (genetics) , medicine , receptor , myocyte , biology , chemistry
Non‐technical summary Exercise improves the ability of skeletal muscle to metabolise fats and sugars. For these improvements to occur the muscle detects a signal caused by exercise, resulting in changes in genes and proteins that control metabolism. We show that endurance exercise increases the amount of a protein called striated muscle activator of Rho signalling (STARS) as well as several other proteins influenced by STARS. We also show that the amount of STARS can be increased by signals directed from proteins called peroxisome proliferator‐activated receptor gamma co‐activator 1‐α (PGC‐1α) and oestrogen‐related receptor‐α (ERRα). We also observed that when we reduce the amount of STARS in muscle cells, we block the ability of PGC‐1α/ERRα to increase a gene called carnitine palmitoyltransferase‐1β (CPT‐1β), which is important for fat metabolism. Our study has shown that the STARS pathway is regulated by endurance exercise. STARS may also play a role in fat metabolism in muscle.