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Single‐unit muscle sympathetic nervous activity and its relation to cardiac noradrenaline spillover
Author(s) -
Lambert Elisabeth A.,
Schlaich Markus P.,
Dawood Tye,
Sari Carolina,
Chopra Reena,
Barton David A.,
Kaye David M.,
Elam Mikael,
Esler Murray D.,
Lambert Gavin W.
Publication year - 2011
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.2011.205351
Subject(s) - heart rate , sympathetic nervous system , motor unit , medicine , chemistry , anatomy , blood pressure
Non‐technical summary Recent work has demonstrated differences in the firing pattern of sympathetic nerves in a variety of patient groups. The significance or consequences of this firing pattern remain unknown. We examined whether the nerve firing pattern was associated with increased noradrenaline release from the heart. The activity and pattern of the nerve firing was recorded in the peroneal nerve and subjects were divided into two groups according to the firing pattern as ‘low firing rate’ or ‘high firing rate’. In those with a high firing rate, the noradrenaline released by the heart was two times higher than that of subjects with a low firing rate. This study indicates that the nerve firing pattern may dictate the amount of noradrenaline released by the heart.