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Kinetic control of oxygen consumption during contractions in self‐perfused skeletal muscle
Author(s) -
Wüst Rob C. I.,
Grassi Bruno,
Hogan Michael C.,
Howlett Richard A.,
Gladden L. Bruce,
Rossiter Harry B.
Publication year - 2011
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.2010.203422
Subject(s) - in vivo , oxidative phosphorylation , skeletal muscle , myocyte , oxygen , chemistry , biophysics , biochemistry , microbiology and biotechnology , endocrinology , biology , organic chemistry
Non‐technical summary The ability to sustain exercise is dependent on the ability to match muscular energy supply fuelled by oxygen to the energy demands of the activity (the ‘currency’ of biological energy is termed ATP). Experiments using muscle samples in a test tube suggest that the activation of muscle oxygen consumption is caused by accumulation of ADP (a breakdown product of ATP), which signals the need to increase ATP supply. The mechanism of this signalling process in vivo , however, is not well understood. We investigated the mechanism controlling oxidative ATP supply activation in canine muscle, by simultaneous measurements of oxygen consumption and ADP at the onset of muscle contractions. At the start of contractions muscle oxygen consumption increased more rapidly than predicted from the measured accumulation of ADP. These data suggest that an additional process (or processes) occurs to activate muscle oxidative ATP provision at the onset of exercise in vivo .