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Emerging concepts for the role of TRP channels in the cardiovascular system
Author(s) -
Vennekens Rudi
Publication year - 2011
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.2010.202077
Subject(s) - transient receptor potential channel , ion channel , cardiac hypertrophy , trpc1 , medicine , neuroscience , focus (optics) , chemistry , muscle hypertrophy , cardiology , biology , receptor , physics , optics
The transient receptor potential (TRP) family of ion channels is a large family of cation selective ion channels, which are expressed and functional in a variety of tissues. In this review we focus on the most recent results detailing the role of TRP channels in the cardiovascular system. The presented results underscore the role of TRP channels in cardiomyocytes, smooth cells and endothelium, and in disease states such as hypertension, cardiac conduction block and cardiac hypertrophy.