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Acute and chronic effects of hypercalcaemia on cortical excitability as studied by 5 Hz repetitive transcranial magnetic stimulation
Author(s) -
Iacovelli Elisa,
Gilio Francesca,
Mascia Maria Lucia,
Scillitani Alfredo,
Romagnoli Elisabetta,
Pichiorri Floriana,
Fucile Sergio,
Minisola Salvatore,
Inghilleri Maurizio
Publication year - 2011
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.2010.201111
Subject(s) - transcranial magnetic stimulation , hypercalcaemia , neuroscience , primary motor cortex , synaptic plasticity , motor cortex , neuroplasticity , medicine , asymptomatic , stimulation , neurophysiology , primary hyperparathyroidism , psychology , calcium , receptor
Non‐technical summary Calcium ions play crucial roles in many forms of synaptic plasticity at central nervous system level. We studied the effects of chronic and acute hypercalcaemia on synaptic plasticity in patients with primary hyperparathyroidism and healthy controls by applying over the primary motor cortex a non‐invasive neurophysiological technique named repetitive transcranial magnetic stimulation (rTMS). Our results showed that conditions of hypercalcaemia decreased synaptic plasticity as tested by rTMS. Our results may help to understand the mechanisms underlying neuronal dysfunctions during hypercalcaemia and to evaluate asymptomatic patients.