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Etomidate and propofol inhibit the neurotransmitter release machinery at different sites
Author(s) -
Herring Bruce E.,
McMillan Kyle,
Pike Carolyn M.,
Marks Jeremy,
Fox Aaron P.,
Xie Zheng
Publication year - 2011
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.2010.200964
Subject(s) - etomidate , neurotransmitter , propofol , neurotransmitter systems , mechanism of action , neuroscience , pharmacology , mechanism (biology) , chemistry , medicine , biology , central nervous system , dopamine , in vitro , biochemistry , philosophy , epistemology
Non‐technical summary Alterations in synaptic efficacy are thought to underlie changes in learning and behaviour and are vital to normal neuronal function. Using a variety of different cells and techniques we investigate whether anaesthetics can modify neurotransmitter release as part of their mechanism of action. Our data suggest that inhibition of neurotransmitter release may be a critical mechanism for the actions of anaesthetics like etomidate and propofol. In the future this information may be used to design new generations of clinically useful anaesthetics.