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Retinoic acid stimulation of VEGF secretion from human endometrial stromal cells is mediated by production of reactive oxygen species
Author(s) -
Wu Juanjuan,
Hansen Jason M.,
Hao Lijuan,
Taylor Robert N.,
Sidell Neil
Publication year - 2011
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.2010.200808
Subject(s) - stromal cell , retinoic acid , vascular endothelial growth factor , secretion , endometrium , stimulation , angiogenesis , reactive oxygen species , microbiology and biotechnology , endocrinology , medicine , chemistry , cancer research , vegf receptors , vascular endothelial growth factor a , growth factor , biology , cell culture , receptor , genetics
Non‐technical summary Vascular endothelial growth factor (VEGF) is an angiogenic factor that plays a primary role in blood vessel development in uterine endometrial tissue during embryo implantation and early growth. Previously, we determined that retinoic acid (RA) can act as a co‐factor to rapidly induce VEGF secretion from human endometrial stromal cells. We show here that stimulation of VEGF by RA is directly mediated by increased production of reactive oxygen species (ROS) in these cells. These findings predict a ROS‐mediated mechanism for RA regulation of localized VEGF secretion in the human endometrium that may be necessary for the successful establishment of pregnancy. The results obtained may provide new targets for therapeutic intervention.