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Functional and developmental expression of a zebrafish Kir1.1 (ROMK) potassium channel homologue Kcnj1
Author(s) -
Abbas Leila,
Hajihashemi Saeed,
Stead Lucy F.,
Cooper Gordon J.,
Ware Tracy L.,
Munsey Tim S.,
Whitfield Tanya T.,
White Stanley J.
Publication year - 2011
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.2010.200295
Subject(s) - zebrafish , reabsorption , potassium channel , microbiology and biotechnology , ion channel , potassium , biology , aquaporin , chemistry , kidney , biophysics , biochemistry , endocrinology , gene , receptor , organic chemistry
Non‐technical summary Due to the conservation of developmental pathways and genetic material over the course of evolution, non‐mammalian ‘model organisms’ such as the zebrafish embryo are emerging as valuable tools to explore causes and potential treatments for human diseases. Ion channels are proteins that form pores and help to establish and control electrical gradients by allowing the flow of ions across biological membranes. A diverse range of key physiological mechanisms in every organ in the body depends on the activity of ion channels. In this paper, we show that a potassium‐selective channel that underlies salt reabsorption and potassium excretion in the human kidney is also expressed in zebrafish in cells that are important regulators of salt balance. Disruption of the channel's expression in zebrafish leads to effects on the activity of the heart, consistent with a role for this channel in the control of potassium balance in the embryo.