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Renal mechanisms contributing to the antihypertensive action of soluble epoxide hydrolase inhibition in Ren‐2 transgenic rats with inducible hypertension
Author(s) -
Honetschlägerová Zuzana,
Husková Zuzana,
Vaňourková Zdeňka,
Sporková Alexandra,
Kramer Herbert J.,
Hwang Sung Hee,
Tsai HsingJu,
Hammock Bruce D.,
Imig John D.,
Červenka Luděk,
Kopkan Libor
Publication year - 2011
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.2010.199505
Subject(s) - pacemaker potential , chemistry , medicine , anatomy , electrophysiology , endocrinology , biology
Non‐technical summary Arachidonic acid metabolites called epoxyeicosatrienoic acids (EETs) influence vascular tone and renal tubular sodium and water transport and thus have been implicated in the control of blood pressure. Inhibition of the enzyme soluble epoxide hydrolase (sEH), which reduces EET degradation to the corresponding diols, leads to substantial attenuation of malignant hypertension in a transgenic rat strain harbouring the mouse renin gene particularly via an improvement of renal function. The observed antihypertensive and renoprotective effects of this novel pharmacological approach provide a potentially new direction in antihypertensive therapy.