Premium
Synaptic vesicles control the time course of neurotransmitter secretion via a Ca 2+ /H + antiport
Author(s) -
Cordeiro J. Miguel,
Gonçalves Paula P.,
Dunant Yves
Publication year - 2011
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.2010.199224
Subject(s) - antiporter , synaptic vesicle , neurotransmitter , vesicle , biophysics , chemistry , neuroscience , neurotransmission , microbiology and biotechnology , membrane , biochemistry , biology , receptor
Non‐technical summary A low‐affinity Ca 2+ /H + antiport has been described in the membrane of synaptic vesicles isolated from mammalian brain cortex. We show here evidence that the role of the vesicular Ca 2+ /H + antiport is to shorten the time course of transmitter release during individual nerve impulses. The process seems of great importance since it can enable rapid synapses to transmit briefer signals, and so work at high frequencies.