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The dynamics of single spike‐evoked adenosine release in the cerebellum
Author(s) -
Klyuch Boris P.,
Richardson Magnus J. E.,
Dale Nicholas,
Wall Mark J.
Publication year - 2011
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.2010.198986
Subject(s) - cerebellum , spike (software development) , neuroscience , adenosine , dynamics (music) , chemistry , biophysics , psychology , biology , computer science , biochemistry , pedagogy , software engineering
Non‐technical summary Adenosine modulates brain activity in both health and disease. Although we know a lot about adenosine action, we know little about how it is released and its cellular sources. We have previously shown that adenosine can be released in the cerebellum by a train of action potentials. Here we have used a pharmacological agent to enhance adenosine release and can thus study release in response to a single action potential. The release follows a waveform that is well described by a minimal diffusion model from a temporally sharp release event. Adenosine release has a complex, history‐dependent dynamics: it can be either depressed or enhanced depending on the stimulation pattern – similar properties to those of fast neurotransmitters such as glutamate. Our results demonstrate that the dynamics of adenosine release will depend strongly on the pattern of neural activity and thus constitutes a highly complex signalling pathway in the nervous system.