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Requirement for CB1 but not GABA B receptors in the cholecystokinin mediated inhibition of GABA release from cholecystokinin expressing basket cells
Author(s) -
Lee SangHun,
Soltesz Ivan
Publication year - 2011
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.2010.198499
Subject(s) - cholecystokinin , neuroscience , cannabinoid receptor , hippocampal formation , cannabinoid , neuropeptide , cholecystokinin receptor , inhibitory postsynaptic potential , hippocampus , receptor , biology , chemistry , antagonist , biochemistry
Non technical summary Cholecystokinin (CCK) is a widely expressed neuropeptide known to play key roles in both normal behaviour and pathophysiological conditions. Previous reports suggested that CCK serves as a unique molecular switch that differentially regulates the output of distinct types of inhibitory interneurons in the hippocampus. The current study focused on the underlying mechanisms of the CCK actions on hippocampal interneurons, and the results show that CCK modulates transmitter release from a major class of interneurons through cannabinoid type‐1 receptor signalling mechanisms. Taken together, the present data will help us better understand how CCK modulates neuronal circuits in the brain.