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Skeletal muscle fatigue precedes the slow component of oxygen uptake kinetics during exercise in humans
Author(s) -
Can Daniel T.,
White Ailish C.,
Andriano Melina F.,
Kolkhorst Fred W.,
Rossiter Harry B.
Publication year - 2011
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.2010.197723
Subject(s) - muscle fatigue , physical exercise , work (physics) , exercise physiology , oxygen , exercise intensity , skeletal muscle , exercise intolerance , intensity (physics) , mechanism (biology) , physical medicine and rehabilitation , medicine , chemistry , electromyography , heart rate , blood pressure , mechanical engineering , heart failure , physics , philosophy , organic chemistry , epistemology , quantum mechanics , engineering
Non‐technical summary The mechanisms determining exercise intolerance are poorly understood. A reduction in work efficiency in the form of an additional energy cost and oxygen requirement occurs during high‐intensity exercise and contributes to exercise limitation. Muscle fatigue and subsequent recruitment of poorly efficient muscle fibres has been proposed to mediate this decline. These data demonstrate in humans, that muscle fatigue, generated in the initial minutes of exercise, is correlated with the increasing energy demands of high‐intensity exercise. Surprisingly, however, while muscle fatigue reached a plateau, oxygen uptake continued to increase throughout 8 min of exercise. This suggests that additional recruitment of inefficient muscle fibres may not be the sole mechanism contributing to the decline in work efficiency during high‐intensity exercise.