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Effect of P2 receptor blockade with pyridoxine on sympathetic response to exercise pressor reflex in humans
Author(s) -
Cui Jian,
Leuenberger Urs A.,
Blaha Cheryl,
King Nicholas C.,
Sinoway Lawrence I.
Publication year - 2011
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.2010.196709
Subject(s) - reflex , medicine , endocrinology , isometric exercise , blood pressure , sympathetic nervous system , pyridoxine
Non‐technical summary During exercise, sympathetic nervous system activity increases and this contributes to an increase in blood pressure (i.e. exercise pressor reflex). Although animal studies suggest that purinergic P2 receptors on thin fibre sensory nerves are stimulated and evoke this reflex, human data are lacking. In this study, young healthy volunteers performed fatiguing isometric handgrip before and after a local infusion of pyridoxine (i.e. vitamin B 6 ) into the ‘isolated’ circulation of the human forearm. Pyridoxine is converted into a P2‐purinoceptor antagonist. Muscle sympathetic nerve activity and blood pressure responses to fatiguing handgrip and post‐exercise circulatory occlusion were significantly less after pyridoxine than they were before. These effects were not observed after infusion of saline. These data suggest that P2 receptors contribute to the exercise pressor reflex in humans.