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Plasma pH does not influence the cerebral metabolic ratio during maximal whole body exercise
Author(s) -
Volianitis S.,
Rasmussen P.,
Seifert T.,
Nielsen H. B.,
Secher N. H.
Publication year - 2011
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.2010.195636
Subject(s) - rowing , metabolic acidosis , acidosis , medicine , endocrinology , metabolism , bicarbonate , chemistry , archaeology , history
Non‐technical summary Exercise is known to promote the use of lactate as metabolic fuel for the brain. As a result the cerebral metabolic ratio, an index of the brain's metabolism, is reduced compared to rest. It is not known whether the exercise‐induced metabolic acidosis affects cerebral metabolism and the reduction of the cerebral metabolic ratio. We manipulated the metabolic acidosis by infusing bicarbonate in well trained rowers during a maximal rowing ergometer effort. We show that elimination of acidosis does not affect the reduction of the cerebral metabolic ratio. Furthermore, the data indicate that the capacity of the brain to take up lactate may have a limit. This indication requires further evaluation.