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Excitatory amino acid involvement in dendritic spine formation, maintenance and remodelling
Author(s) -
McKinney R. Anne
Publication year - 2010
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.2009.178905
Subject(s) - dendritic spine , excitatory postsynaptic potential , ampa receptor , dendritic filopodia , neuroscience , nmda receptor , ionotropic effect , synapse , glutamate receptor , chemistry , biology , inhibitory postsynaptic potential , receptor , hippocampal formation , biochemistry
In the central nervous system, most excitatory synapses occur on dendritic spines, which are small protrusions from the dendritic tree. In the mature cortex and hippocampus, dendritic spines are heterogeneous in shape. It has been shown that the shapes of the spine can affect synapse stability and synaptic function. Dendritic spines are highly motile structures that can undergo actin‐dependent shape changes, which occur over a time scale ranging from seconds to tens of minutes or even days. The formation, remodelling and elimination of excitatory synapses on dendritic spines represent ways of refining the microcircuitry in the brain. Here I review the current knowledge on the effects of modulation of AMPA and NMDA ionotropic glutamate receptors on dendritic spine formation, motility and remodelling.