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Diverse transport modes by the solute carrier 26 family of anion transporters
Author(s) -
Ohana Ehud,
Yang Dongki,
Shcheynikov Nikolay,
Muallem Shmuel
Publication year - 2009
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.2008.164863
Subject(s) - transporter , solute carrier family , chemistry , function (biology) , ion transporter , cotransporter , membrane transport protein , secretion , biophysics , biochemistry , organic anion transporter 1 , microbiology and biotechnology , biology , membrane , sodium , gene , organic chemistry
The solute carrier 26 (SLC26) transporters are anion transporters with diverse substrate specificity. Several members are ubiquitous while others show limited tissue distribution. They are expressed in many epithelia and to the extent known, play a central role in anion secretion and absorption. Members of the family are primarily Cl − transporters, although some members transport mainly SO 4 2− , Cl − , HCO 3 − or I − . A defining feature of the family is their functional diversity. Slc26a1 and Slc26a2 function as specific SO 4 2− transporters while Slc26a4 functions as an electroneutral Cl − /I − /HCO 3 − exchanger. Slc26a3 and Slc26a6 function as coupled electrogenic Cl − /HCO 3 − exchangers or as bona fide anion channels. SLC26A7 and SLC26A9 function exclusively as Cl − channels. This short review discusses the functional diversity of the SLC26 transporters.