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Nutritional regulation of glucagon‐like peptide‐1 secretion
Author(s) -
Tolhurst Gwen,
Reimann Frank,
Gribble Fiona M.
Publication year - 2009
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.2008.164012
Subject(s) - postprandial , glucose homeostasis , glucagon like peptide 1 , bombesin , endogeny , nutrient sensing , ingestion , appetite , biology , homeostasis , glucagon like peptide 2 , microbiology and biotechnology , secretion , glucagon , endocrinology , peptide , signal transduction , neuropeptide , insulin , type 2 diabetes , biochemistry , receptor , diabetes mellitus , insulin resistance
Glucagon‐like peptide‐1 (GLP‐1), released from L‐ cells in the intestinal epithelium, plays an important role in postprandial glucose homeostasis and appetite control. Following the recent therapeutic successes of antidiabetic drugs aimed at either mimicking GLP‐1 or preventing its degradation, attention is now turning towards the L‐cell, and addressing whether it would be both possible and beneficial to stimulate the endogenous release of GLP‐1 in vivo . Understanding the mechanisms underlying GLP‐1 release from L‐cells is key to this type of approach, and the use of cell line models has led to the identification of a variety of pathways that may underlie the physiological responses of L‐cells to food ingestion. This review focuses on our current understanding of the signalling mechanisms that underlie L‐cell nutrient responsiveness.