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Voltage‐sensing phosphatase: actions and potentials
Author(s) -
Okamura Yasushi,
Murata Yoshimichi,
Iwasaki Hirohide
Publication year - 2009
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.2008.163097
Subject(s) - voltage , phosphatase , membrane potential , ion channel , ion , biophysics , chemistry , physics , electrical engineering , biology , engineering , biochemistry , phosphorylation , receptor , organic chemistry
Voltage sensors have been well studied in voltage‐gated ion channels for neuronal excitation and muscle contraction. The recent discovery of a voltage‐sensing phosphatase, VSP, has changed the idea that voltage sensors are unique to ion flux through membranes. Recent findings on mechanisms and potential applications of VSP are reviewed.