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Cytoplasmic calcium oscillations and store‐operated calcium influx
Author(s) -
Putney James W.,
Bird Gary S.
Publication year - 2008
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.2008.153221
Subject(s) - calcium , calcium signaling , cytoplasm , microbiology and biotechnology , calcium in biology , intracellular , biophysics , signalling , biology , chemistry , organic chemistry
Intracellular calcium oscillations have fascinated scientists for decades. They provide an important cellular signal which, unlike most signalling mechanisms, is digitally encoded. While it is generally agreed that oscillations most frequently arise from cyclical release and re‐uptake of intracellularly stored calcium, it is becoming increasingly clear that influx of calcium across the plasma membrane also plays a critical role in their maintenance and even in delivering their signal to the correct cellular locus. In this review we will discuss the role played by Ca 2+ entry mechanisms in Ca 2+ oscillations, and approaches to understanding the molecular nature of this Ca 2+ entry pathway.