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Cell tracking using magnetic resonance imaging
Author(s) -
Hoehn Mathias,
Wiedermann Dirk,
Justicia Carles,
RamosCabrer Pedro,
Kruttwig Klaus,
Farr Tracy,
Himmelreich Uwe
Publication year - 2007
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.2007.139451
Subject(s) - magnetic resonance imaging , functional magnetic resonance imaging , labelling , cell , nuclear magnetic resonance , computer science , neuroscience , tracking (education) , biology , physics , medicine , radiology , psychology , pedagogy , biochemistry , genetics
Cell tracking by in vivo magnetic resonance imaging (MRI) requires strategies of labelling the cells with MRI contrast agents. The principal routes to achieve efficient cell labelling for neurological applications are discussed with methodological advantages and caveats. Beyond temporo‐spatial localization of labelled cells, the investigation of functional cell status is of great interest to allow studies of functional cell dynamics. The two major approaches to reach this goal, use of responsive contrast agents and generation of transgenic cell lines, are discussed.