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Phospholipases and fatty acid signalling in exocytosis
Author(s) -
Darios Frédéric,
Connell Emma,
Davletov Bazbek
Publication year - 2007
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.2007.136812
Subject(s) - exocytosis , microbiology and biotechnology , lipid bilayer fusion , munc 18 , vesicle , arachidonic acid , polyunsaturated fatty acid , vesicle fusion , biology , chemistry , biochemistry , synaptic vesicle , fatty acid , membrane , enzyme
Vesicle fusion is a ubiquitous biological process involved in general membrane trafficking and a variety of specialized events, for example release of neurotransmitters and hormones, sperm acrosome exocytosis, plasma membrane repair and neurite outgrowth. Many vesicle fusion events have long been known to be activated by phospholipases and products of their activity, such as polyunsaturated arachidonic acid. Polyunsaturated fatty acids (PUFAs) have been proposed to have a number of multiple effectors, including ion channels and the cytoskeleton, but the precise mechanism of PUFA action is still unclear. It was recently reported that omega‐3 and omega‐6 PUFAs can act on syntaxin, a plasma membrane protein directly involved in vesicle fusion. In this review, we will discuss the role of this new mode of PUFA action in exocytosis.