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Soluble erythropoietin receptor is present in the mouse brain and is required for the ventilatory acclimatization to hypoxia
Author(s) -
Soliz Jorge,
Gassmann Max,
Joseph Vincent
Publication year - 2007
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.2007.133454
Subject(s) - erythropoietin , erythropoietin receptor , hypoxia (environmental) , acclimatization , hypoxic ventilatory response , downregulation and upregulation , receptor , regulator , ventilation (architecture) , biology , endocrinology , medicine , chemistry , respiratory system , oxygen , biochemistry , mechanical engineering , botany , organic chemistry , gene , engineering
While erythropoietin (Epo) and its receptor (EpoR) have been widely investigated in brain, the expression and function of the soluble Epo receptor (sEpoR) remain unknown. Here we demonstrate that sEpoR, a negative regulator of Epo's binding to the EpoR, is present in the mouse brain and is down‐regulated by 62% after exposure to normobaric chronic hypoxia (10% O 2 for 3 days). Furthermore, while normoxic minute ventilation increased by 58% in control mice following hypoxic acclimatization, sEpoR infusion in brain during the hypoxic challenge efficiently reduced brain Epo concentration and abolished the ventilatory acclimatization to hypoxia (VAH). These observations imply that hypoxic downregulation of sEpoR is required for adequate ventilatory acclimatization to hypoxia, thereby underlying the function of Epo as a key factor regulating oxygen delivery not only by its classical activity on red blood cell production, but also by regulating ventilation.