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Modulation of TRPs by PIPs
Author(s) -
Voets Thomas,
Nilius Bernd
Publication year - 2007
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.2007.132522
Subject(s) - transient receptor potential channel , ion channel , chemistry , superfamily , neuroscience , biophysics , microbiology and biotechnology , biology , receptor , biochemistry
The TRP superfamily of cation channels encompasses 28 mammalian members related to the product of the Drosophila trp (transient receptor potential) gene. TRP channels have a widespread distribution in many cell types and organs and gate in response to a broad variety of physical and chemical stimuli; as such, they can be considered as ubiquitous cellular sensors. Several recent studies reported modulation of different TRP channels by phosphoinositides, in particular by phosphatidylinositol 4,5‐bisphosphate (PIP 2 ). In most cases, PIP 2 promotes TRP channel activation. Here we provide a brief overview of current insights and controversies about the mechanisms and structural determinants of PIP 2 –TRP channel interactions, and zoom in on the regulation of the Ca 2+ ‐ and voltage‐gated TRPM4 by phosphoinositides.