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The impact of murine strain and sex on postnatal development after maternal dietary restriction during pregnancy
Author(s) -
Knight Brian S.,
Pennell Craig E.,
Adamson S. Lee,
Lye Stephen J.
Publication year - 2007
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.2006.126573
Subject(s) - pregnancy , strain (injury) , medicine , physiology , biology , endocrinology , genetics
The objective of this study was to characterize offspring responses to maternal dietary restriction (DR) in two phylogenetically distant strains of mice: A/J and C57BL/6J (B6). Pregnant mice were fed 100% or 70% of ad libitum between 6.5 and 17.5 days (d) gestation. Offspring were fed 100% ad libitum postweaning. All comparisons were made to strain and sex matched controls. Male DR‐B6 offspring initially grew slower than controls; however, by 77d and 182d they were significantly heavier ( P < 0.05). Further, they had an increase percentage fat mass (+70%, P < 0.01) by 182d and were glucose intolerant at both 80d ( P < 0.001) and 186d ( P < 0.05). In contrast, weight, %Fat mass and glucose tolerance in DR‐A/J males during postnatal life were not different from controls. Female DR‐B6 mice showed catch‐up growth during the first 77d of life; however, their weight, %Fat mass and glucose tolerance were not different from controls at 80d and 186d. Although female DR‐A/J were heavier than controls at 182d ( P < 0.05), their %Fat mass and glucose tolerance were not different from controls at 182d and 186d. The observed strain and sex differences offer a unique opportunity to begin to define gene–environment interactions that contribute to developmental origins of health and disease.