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Effects of hypoxia on diaphragmatic fatigue in highly trained athletes
Author(s) -
Vogiatzis Ioannis,
Georgiadou Olga,
Koskolou Maria,
Athanasopoulos Dimitrios,
Kostikas Konstantinos,
Golemati Spyretta,
Wagner Harrieth,
Roussos Charis,
Wagner Peter D.,
Zakynthinos Spyros
Publication year - 2007
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.2006.126136
Subject(s) - medicine , diaphragmatic breathing , hypoxia (environmental) , muscle fatigue , heart rate , tidal volume , anesthesia , respiratory rate , ventilation (architecture) , cardiology , respiratory system , blood pressure , electromyography , chemistry , oxygen , physical medicine and rehabilitation , mechanical engineering , alternative medicine , organic chemistry , pathology , engineering
Previous work suggests that exercise‐induced arterial hypoxaemia (EIAH), causing only moderate arterial oxygen desaturation (: 92 ± 1%), does not exaggerate diaphragmatic fatigue exhibited by highly trained endurance athletes. Since changes in arterial O 2 tension have a significant effect on the rate of development of locomotor muscle fatigue during strenuous exercise, the present study investigated whether hypoxia superimposed on EIAH exacerbates the exercise‐induced diaphragmatic fatigue in these athletes. Eight trained cyclists (: 67.0 ± 2.6 ml kg −1 min −1 ; mean ± s.e.m. ) completed in balanced order four 5 min exercise tests leading to different levels of end‐exercise (64 ± 2, 83 ± 1, 91 ± 1 and 96 ± 1%) via variations in inspired O 2 fraction (: 0.13, 0.17, 0.21 and 0.26, respectively). Measurements were made at corresponding intensities (65 ± 3, 80 ± 3, 85 ± 3 and 90 ± 3% of normoxic maximal work rate, respectively) in order to produce the same tidal volume, breathing frequency and respiratory muscle load at each . The mean pressure time product of the diaphragm did not differ across the four exercise tests and ranged between 312 ± 28 and 382 ± 22 cmH 2 O s min −1 . Ten minutes into recovery, twitch transdiaphragmatic pressure ( P di,tw ) determined by bilateral phrenic nerve stimulation, was significantly ( P = 0.0001) reduced after all tests. After both hypoxic tests (: 0.13, 0.17) the degree of fall in P di,tw (by 26.9 ± 2.7 and 27.4 ± 2.6%, respectively) was significantly greater ( P < 0.05) than after the normoxic test (by 20.1 ± 3.4%). The greater amount of diaphragmatic fatigue in hypoxia at lower leg work rates (presumably requiring smaller leg blood flow compared with normoxia at higher leg work rates), suggests that when ventilatory muscle load is similar between normoxia and hypoxia, hypoxia exaggerates diaphragmatic fatigue in spite of potentially greater respiratory muscle blood flow availability.