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Multivesicular release and saturation of glutamatergic signalling at retinal ribbon synapses
Author(s) -
Singer Joshua H.
Publication year - 2007
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.2006.125302
Subject(s) - ribbon synapse , postsynaptic potential , glutamatergic , neuroscience , synapse , sensory system , chemistry , biophysics , biology , receptor , membrane , glutamate receptor , biochemistry , synaptic vesicle , vesicle
Pronounced multivesicular release (MVR) occurs at the ribbon synapses of sensory neurones that signal via graded potential changes. As MVR increases the likelihood of postsynaptic receptor saturation, it is of interest to consider how sensory synapses overcome this problem and use MVR to encode signals of widely varying intensities. Here, I discuss three postsynaptic mechanisms that permit three different retinal synapses to utilize MVR.