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Heart repair and stem cells
Author(s) -
Van Laake Linda W.,
Hassink Rutger,
Doevendans Pieter A.,
Mummery Christine
Publication year - 2006
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.2006.115816
Subject(s) - stem cell , context (archaeology) , bone marrow , medicine , myocyte , bone marrow stem cell , myocardial infarction , cell therapy , clinical trial , stem cell therapy , transplantation , cardiology , neuroscience , bioinformatics , biology , microbiology and biotechnology , paleontology
Of the medical conditions currently being discussed in the context of possible treatments based on cell transplantation therapy, few have received more attention than the heart. Much focus has been on the potential application of bone marrow‐derived cell preparations, which have already been introduced into double‐blind, placebo‐controlled clinical trials. The consensus is that bone marrow may have therapeutic benefit but that this is not based on the ability of bone marrow cells to transdifferentiate into cardiac myocytes. Are there potential stem cell sources of cardiac myocytes that may be useful in replacing those lost or dysfunctional after myocardial infarction? Here, this question is addressed with a review of the recent literature.