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Prestin and the cochlear amplifier
Author(s) -
Dallos Peter,
Zheng Jing,
Cheatham Mary Ann
Publication year - 2006
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.2006.114652
Subject(s) - prestin , stereocilia (inner ear) , motor protein , outer hair cells , cochlea , hair cell , neuroscience , microbiology and biotechnology , amplifier , biology , chemistry , physics , optoelectronics , microtubule , cmos
In non‐mammalian, hair cell‐bearing sense organs amplification is associated with mechano‐electric transducer channels in the stereovilli (commonly called stereocilia). Because mammals possess differentiated outer hair cells (OHC), they also benefit from a novel electromotile process, powered by the motor protein, prestin. Here we consider new work pertaining to this protein and its potential role as the mammalian cochlear amplifier.