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Exercise‐induced inhibition of angiotensin II vasoconstriction in human thigh muscle
Author(s) -
Brothers R. Matthew,
Haslund Mads L.,
Wray D. Walter,
Raven Peter B.,
Sander Mikael
Publication year - 2006
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.2006.113977
Subject(s) - vasoconstriction , medicine , angiotensin ii , phenylephrine , femoral artery , endocrinology , vasodilation , methoxamine , cardiology , blood pressure , agonist , receptor
It is well established that metabolic inhibition of adrenergic vasoconstriction contributes to the maintenance of adequate perfusion to exercising skeletal muscle. However, little is known regarding nonadrenergic vasoconstriction during exercise. We tested the hypothesis that a non‐adrenergic vasoconstrictor, angiotensin II (AngII), would be less sensitive to metabolic inhibition than an α 1 ‐agonist, phenylephrine (PE), in the exercising human thigh. In 11 healthy men, femoral blood flow (FBF, ultrasound Doppler and thermodilution) and blood pressure were evaluated during wide‐ranging doses of intra‐arterial (femoral) infusions of PE and AngII at rest and during two workloads of steady‐state knee‐extensor exercise (7 W and 27 W). At rest, the maximal decrease in femoral artery diameter (FAD) during AngII (9.0 ± 0.2 to 8.4 ± 0.4 mm) was markedly less than during PE (9.0 ± 0.3 to 5.7 ± 0.5 mm), whereas maximal reductions in FBF and femoral vascular conductance (FVC) were similar during AngII (FBF: −65 ± 6 and FVC: −66 ± 6%) and PE (−57 ± 5 and −59 ± 4%). During exercise, FAD was not changed by AngII, but moderately decreased by PE. The maximal reductions in FBF and FVC were blunted during exercise compared to rest for both AngII (7 W: −28 ± 5 and −40 ± 5%; 27 W: −15 ± 4% and −29 ± 5%) and PE (7 W: −30 ± 4 and −37 ± 6%; 27 W: −15 ± 2 and −24 ± 6%), with no significant differences between drugs. The major new findings are (1) an exercise‐induced intensity‐dependent metabolic attenuation of non‐adrenergic vasoconstriction in the human leg; and (2) functional evidence that AngII‐vasoconstriction is predominantly distal, whereas α 1 ‐vasoconstriction is proximal and distal within the muscle vascular bed of the human thigh.