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Electrophysiological and gene expression profiling of neuronal cell types in mammalian neocortex
Author(s) -
Yano Kojiro,
Subkhankulova Tatiana,
Livesey Frederick J.,
Robinson Hugh P. C.
Publication year - 2006
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.2006.113712
Subject(s) - neocortex , neuroscience , cell type , biology , gene expression profiling , profiling (computer programming) , electrophysiology , cortex (anatomy) , gene expression , cell , gene , computer science , genetics , operating system
It is a challenging question to understand how different neuronal types are organized into a complex architecture in the cortex, an architecture which is also adapted in different regions to subserve very different functions. Recent developments in genetic and molecular techniques have opened up the possibility of using gene expression profiling for neuronal cell typing, with the aim of uncovering novel cell types and the underlying mechanisms which generate and maintain neuronal heterogeneity in the cortex. This review introduces some current ideas about neuronal cell types in the cortex and describes recent approaches to expression profiling for defining cortical neuronal cell types.