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Transcriptional regulation of neuronal phenotype in mammals
Author(s) -
Ma Qiufu
Publication year - 2006
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.2006.113449
Subject(s) - phenotype , biology , epigenetics , transcription factor , neuroscience , nervous system , regulation of gene expression , transcriptional regulation , gene , gene expression , computational biology , genetics
Transcription factors (TFs) play pivotal roles in directing the formation of neurons and glia. Here I will review the recent genome‐scale analysis of the expression of TFs in the developing mouse nervous system and discuss the logic by which TFs control the establishment of neuronal phenotype. Accumulating evidence suggests that while combinatorial action of TFs is able to define the basic framework of the nervous system, other control mechanisms, such as stochastic and epigenetic regulation of gene expression, also contribute to the generation of nerve cell diversity.