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The role of AMP‐activated protein kinase in mitochondrial biogenesis
Author(s) -
Reznick Richard M.,
Shulman Gerald I.
Publication year - 2006
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.2006.109512
Subject(s) - mitochondrial biogenesis , ampk , amp activated protein kinase , protein kinase a , microbiology and biotechnology , peroxisome , mitochondrion , coactivator , organelle biogenesis , biogenesis , ppargc1a , insulin resistance , biology , chemistry , kinase , endocrinology , biochemistry , receptor , insulin , gene , transcription factor
While it has been known for more than 75 years that physical activity is associated with increased mitochondrial content in muscle, the molecular mechanism for this adaptive process has only recently been elucidated. This brief review examines existing studies that have identified AMPK‐activated protein kinase (AMPK) and several other key regulators of mitochondrial biogenesis, including peroxisome proliferator‐activated receptor‐γ coactivator‐1α and ‐1β, calcium/calmodulin‐dependent protein kinase IV, and nitric oxide. In addition, the potential role of mitochondrial dysfunction in the pathogenesis of insulin resistance associated with ageing and type 2 diabetes mellitus is also discussed.