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Preparing for the first breath: prenatal maturation of respiratory neural control
Author(s) -
Greer John J.,
Funk Gregory D.,
Ballanyi Klaus
Publication year - 2006
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.2005.097238
Subject(s) - respiratory system , control of respiration , diaphragm (acoustics) , medicine , neuroscience , rhythm , ventilation (architecture) , respiratory center , respiratory physiology , anesthesia , biology , engineering , mechanical engineering , loudspeaker , electrical engineering
By birth, the regulatory neural network responsible for respiratory control is capable of generating robust rhythm‐driving ventilation that can adjust to homeostatic needs. The advent of in vitro models isolated from prenatal rodents has significantly advanced our understanding of these processes. In this topical review, we examine the development of medullary respiratory rhythm‐generating centres and phrenic motoneurone–diaphragm properties during the prenatal period.