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Aspects of the homeostaic plasticity of GABA A receptor‐mediated inhibition
Author(s) -
Mody Istvan
Publication year - 2004
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.2004.077362
Subject(s) - homeostatic plasticity , neuroscience , plasticity , excitatory postsynaptic potential , synaptic plasticity , biology , neuroplasticity , metaplasticity , nonsynaptic plasticity , inhibitory postsynaptic potential , tonic (physiology) , homeostasis , homosynaptic plasticity , developmental plasticity , ion channel , receptor , microbiology and biotechnology , biochemistry , physics , synaptic fatigue , thermodynamics
Plasticity of ligand‐gated ion channels plays a critical role in nervous system development, circuit formation and refinement, and pathological processes. Recent advances have mainly focused on the plasticity of channels gated by excitatory amino acids, including their acclaimed role in learning and memory. These receptors, together with voltage‐gated ion channels, have also been known to be subjected to a homeostatic form of plasticity that prevents destabilization of the neurone's function and that of the network during various physiological processes. To date, the plasticity of GABA A receptors has been examined mainly from a developmental and a pathological point of view. Little is known about homeostatic mechanisms governing their plasticity. This review summarizes some of the findings on the homeostatic plasticity of tonic and phasic inhibitory activity.