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The ‘window’ T‐type calcium current in brain dynamics of different behavioural states
Author(s) -
Crunelli Vincenzo,
Tóth Tibor I.,
Cope David W.,
Blethyn Kate,
Hughes Stuart W.
Publication year - 2004
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.2004.076273
Subject(s) - neuroscience , dynamics (music) , calcium , current (fluid) , window (computing) , type (biology) , psychology , biology , physics , computer science , medicine , acoustics , ecology , thermodynamics , operating system
All three forms of recombinant low voltage‐activated T‐type Ca 2 + channels (Ca v 3.1, Ca v 3.2 and Ca v 3.3) exhibit a small, though clearly evident, window T‐type Ca 2 + current ( I Twindow ) which is also present in native channels from different neuronal types. In thalamocortical (TC) and nucleus reticularis thalami (NRT) neurones, and possibly in neocortical cells, an I Twindow ‐mediated bistability is the key cellular mechanism underlying the expression of the slow (< 1 Hz) sleep oscillation, one of the fundamental EEG rhythms of non‐REM sleep. As the I Twindow ‐mediated bistability may also represent one of the cellular mechanisms underlying the expression of high frequency burst firing in awake conditions, I Twindow is of critical importance in neuronal population dynamics associated with different behavioural states.