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The impact of splice isoforms on voltage‐gated calcium channel α 1 subunits
Author(s) -
JurkatRott Karin,
LehmannHorn Frank
Publication year - 2004
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.2003.052712
Subject(s) - alternative splicing , splice , exon , gene isoform , rna splicing , calcium channel , microbiology and biotechnology , protein subunit , biology , voltage dependent calcium channel , messenger rna , gene , genetics , rna , chemistry , calcium , organic chemistry
Semi‐conserved exon boundaries in members of the CACNA1 gene family result in recurring pre‐mRNA splicing patterns. The resulting variations in the encoded pore‐forming subunit of the voltage‐gated calcium channel affect functionally significant regions, such as the vicinity of the voltage‐sensing S4 segments or the intracellular loops that are important for protein interaction. In addition to generating functional diversity, RNA splicing regulates the quantitative expression of other splice isoforms of the same gene by producing transcripts with premature stop codons which encode two‐domain or three‐domain channels. An overview of some of the known splice isoforms of the α 1 calcium channel subunits and their significance is given.