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Endocytosis at the synaptic terminal
Author(s) -
Royle Stephen J.,
Lagnado Leon
Publication year - 2003
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.2003.049221
Subject(s) - exocytosis , endocytosis , synaptic vesicle , vesicle , kiss and run fusion , synapse , synaptic vesicle recycling , neurotransmitter , bulk endocytosis , vesicle fusion , microbiology and biotechnology , chemistry , biology , biophysics , neuroscience , membrane , cell , biochemistry , central nervous system
Exocytosis of neurotransmitter from a synaptic vesicle is followed by efficient retrieval of its constituent membrane and proteins. Real‐time measurements indicate that fast and slow modes of retrieval operate in parallel at a number of presynaptic terminals. Two mechanisms can be distinguished by electron microscopy: clathrin‐mediated retrieval of small vesicles and bulk retrieval of large cisternae. Methods that investigate the behaviour of individual vesicles have recently demonstrated a third route of retrieval: the rapid reversal of a pore‐like connection between the vesicle and surface (‘kiss‐and‐run’). Key aims for the future are to identify the molecules underlying different mechanisms of endocytosis at the synapse and the signals that select between them.