Enhancement of presynaptic calcium current by cysteine string protein | Zendy

Chen Shan | Zendy; Zheng Xu | Zendy; Schulze Karen L. | Zendy; Morris Terry | Zendy; Bellen Hugo | Zendy; Stanley Elis F. | Zendy

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Enhancement of presynaptic calcium current by cysteine string protein

Author(s) -

Chen Shan,

Zheng Xu,

Schulze Karen L.,

Morris Terry,

Bellen Hugo,

Stanley Elis F.

Publication year - 2002

Publication title -

the journal of physiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.802

H-Index - 240

eISSN - 1469-7793

pISSN - 0022-3751

DOI - 10.1113/jphysiol.2001.013397

Subject(s) - biophysics , endogeny , chemistry , vesicle , cysteine , microbiology and biotechnology , synaptic vesicle , synapse , voltage dependent calcium channel , neuroscience , calcium , biology , biochemistry , organic chemistry , membrane , enzyme

The isolated chick ciliary neuron calyx synapse preparation was used to test cysteine string protein (CSP) action on presynaptic N‐type Ca 2+ channels. Endogenous CSP was localized primarily to secretory vesicle clusters in the presynaptic nerve terminal. Introduction of recombinant CSP into the voltage clamped terminal resulted in a prominent increase in Ca 2+ current amplitude. However, this increase could not be attributed to a change in Ca 2+ channel kinetics, voltage dependence, prepulse inactivation, or G protein inhibition but was attributed to the recruitment of dormant channels. Secretory vesicle associated endogenous CSP may play an important role in enhancing Ca 2+ channel activity at the transmitter release site.

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