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Inhibition of nitric oxide synthase does not alter ocular dominance shifts in kitten visual cortex.
Author(s) -
Reid S N,
Daw N W,
Czepita D,
Flavin H J,
Sessa W C
Publication year - 1996
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.1996.sp021509
Subject(s) - kitten , monocular deprivation , nitric oxide synthase , visual cortex , nitric oxide , ocular dominance , neuroscience , hippocampus , sensory system , chemistry , endocrinology , biology , medicine , psychology , cats
1. Since nitric oxide has been proposed as a feedback factor in plasticity in the hippocampus, we tested whether it might also be a feedback factor in sensory‐dependent plasticity in the cat visual cortex. 2. The effects of monocular deprivation were compared between eight hemispheres with infusion of a nitric oxide synthase inhibitor, and eight control hemispheres with either infusion of the inactive isomer, or no infusion. Although nitric oxide synthase activity was reduced significantly, the ocular dominance histograms were not substantially different in the two groups of animals. We conclude that the feedback factor for sensory‐dependent plasticity in the visual cortex is likely to be some factor other than nitric oxide.