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Hypothalamic interaction between macrophage inflammatory protein‐1 alpha (MIP‐1 alpha) and MIP‐1 beta in rats: a new level for fever control?
Author(s) -
Miñano F J,
Fernández-Alonso A,
Myers R D,
Sancibrián M
Publication year - 1996
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.1996.sp021208
Subject(s) - alpha (finance) , beta (programming language) , macrophage inflammatory protein , macrophage , immunology , inflammation , medicine , chemistry , biology , chemokine , biochemistry , computer science , construct validity , patient satisfaction , programming language , nursing , in vitro
1. The microinjection of macrophage inflammatory protein‐1 (MIP‐1 alpha; 5.0 and 25 pg) into the anterior hypothalamic, preoptic area (AHPOA) induced a slow onset; monophasic fever in rats that persisted for a long period. Microinjection of 25 pg MIP‐1 beta into the AHPOA induced a fever of rapid onset, whereas 5.0 pg MIP‐1 beta did not alter body temperature (Tb) significantly. When either MIP‐1 alpha or MIP‐1 beta was heated to 70 degrees C for 30 min prior to their injection, no pyrexic response was produced. 2. The concurrent microinjection of 25 pg MIP‐1 alpha and 25 pg MIP‐1 beta into the AHPOA attenuated the effects on Tb of either cytokine alone. However, pretreatment with either 5.0 pg MIP‐1 beta or 5.0 pg MIP‐1 alpha suppressed the febrile response induced by 25 pg MIP‐1 alpha or 25 pg MIP‐1 beta, given at the same site, respectively. 3. The present experiments show that MIP‐1 alpha and MIP‐1 beta are active individually and possess distinct differences in their evocation of a febrile response. Further, our results suggest a functional antagonism between MIP‐1 alpha and MIP‐1 beta that could represent a new level in the development of fever.