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Structure/function studies of mammalian Na‐H exchangers‐‐an update.
Author(s) -
Yun C H,
Tse C M,
Nath S,
Levine S L,
Donowitz M
Publication year - 1995
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.1995.sp020558
Subject(s) - sodium–hydrogen antiporter , gene isoform , microbiology and biotechnology , function (biology) , chemistry , computational biology , biophysics , biology , biochemistry , sodium , gene , organic chemistry
Four mammalian Na+/H+ exchangers have recently been cloned. Despite the structural similarity, these Na+/H+ exchanger isoforms differ in kinetic characteristics and their response to external stimuli. The present review deals with the recent developments in their functional characterization and their short‐term regulation.