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Permeability of the human placenta in vivo to four non‐metabolized hydrophilic molecules.
Author(s) -
Bain M D,
Copas D K,
Taylor A,
Landon M J,
Stacey T E
Publication year - 1990
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.1990.sp018343
Subject(s) - mannitol , in vivo , chemistry , ethylenediaminetetraacetic acid , permeability (electromagnetism) , placenta , population , inulin , chromatography , biochemistry , fetus , pregnancy , medicine , biology , membrane , organic chemistry , chelation , genetics , microbiology and biotechnology , environmental health
1. Permeability of the human placenta to four permeants of different molecular size was measured at Caesarean section in seven normal full‐term pregnancies. 2. Placental clearance for mannitol was 8.7 +/‐ 1.1 ml min‐1 (mean +/‐ S.E.M.), lactulose 6.3 +/‐ 0.8, chromium ethylenediaminetetraacetic acid (CrEDTA) 3.7 +/‐ 0.5, and inulin 0.98 +/‐ 0.1. 3. The permeability data were analysed in terms of restricted diffusion through ‘notional’ water‐filled pores and found to be incompatible with a single population of uniform pores.