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Small diameter myelinated afferents produce vasodilatation but not plasma extravasation in rat skin.
Author(s) -
Jänig W,
Lisney S J
Publication year - 1989
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.1989.sp017732
Subject(s) - antidromic , axon reflex , extravasation , vasodilation , saphenous nerve , axon , reflex , afferent , stimulation , chemistry , anatomy , cutaneous nerve , anesthesia , medicine , pathology
1. Antidromic stimulation of the rat saphenous nerve at intensities sufficient to excite small myelinated (A delta) fibres but not unmyelinated (C) fibres produced evidence of a transient increase in skin blood flow in the saphenous nerve territory. The magnitude and time course of the vasodilatation depended on the number and frequency of stimuli delivered to the nerve. 2. There was no evidence of an accompanying plasma extravasation. 3. The results suggest that A delta afferent fibres are involved in axon reflex/axon response reactions as well as unmyelinated (C) afferent fibres.