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Co‐ordinated variations in chloride‐dependent potassium transport and cell water in normal human erythrocytes.
Author(s) -
Stewart G W
Publication year - 1988
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.1988.sp017148
Subject(s) - diuretic , potassium , tonicity , chemistry , chloride , water transport , biophysics , sodium , cell , endocrinology , loop (graph theory) , medicine , biochemistry , biology , mathematics , organic chemistry , combinatorics , water flow , environmental engineering , engineering
1.The capacity of the loop‐diuretic‐sensitive Na+‐K+‐Cl‐ system in normal human erythrocytes shows tenfold interindividual variation between different donors, although the transport rate is constant from month to month for any one donor. 2. The present work shows that this variation in Na+‐K+‐Cl‐ transport is inversely correlated with a low‐capacity loop‐diuretic‐insensitive K+ transport, which is chloride dependent and is stimulated by cell swelling in hypotonic media. 3. These variations in K+ transport from donor to donor are related to cell water. Those donors who show high loop‐diuretic‐sensitive Na+‐K+‐Cl‐ co‐transport have lower cell water and vice versa.