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In vivo permeability of the human placenta to inulin and mannitol.
Author(s) -
Bain M D,
Copas D K,
Landon M J,
Stacey T E
Publication year - 1988
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.1988.sp017082
Subject(s) - transplacental , inulin , mannitol , in vivo , excretion , chemistry , bolus (digestion) , fetus , placenta , offspring , endocrinology , medicine , pregnancy , biology , biochemistry , genetics , microbiology and biotechnology
1. Permeability of the term human placenta to inulin and mannitol was measured in six normal pregnancies. 2. Bolus and continuous infusion of inulin and mannitol to the mother for 1‐2 h before delivery by Caesarean section achieved steady‐state maternal serum concentrations. Net accumulation of inulin and mannitol in the fetus was measured by the subsequent neonatal urinary excretion. 3. Transplacental clearance was calculated by dividing the net flux by the time‐averaged transplacental concentration gradient. Clearance for inulin was 0.86 +/‐ 0.1 ml min‐1 (mean +/‐ S.E.M.) and for mannitol 7.3 +/‐ 0.8 ml min‐1 (n = 6 in both cases).