Premium
Fever and acute phase response induced in rabbits by human recombinant interferon‐gamma.
Author(s) -
Morimoto A,
Murakami N,
Takada M,
Teshirogi S,
Watanabe T
Publication year - 1987
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.1987.sp016734
Subject(s) - endogeny , interferon gamma , recombinant dna , pharmacology , acute phase protein , medicine , dose dependence , chemistry , immunology , endocrinology , cytokine , inflammation , biochemistry , gene
1. Intravenous (I.V.) and intracerebroventricular (I.C.V.) injections of human recombinant interferon‐gamma (IFN‐gamma) produced dose‐dependent fevers in rabbits. The fever induced by I.V. injection was monophasic and the maximum elevation occurred 80‐110 min after injection. The fever induced by I.C.V. injection was observed from about 20 min after injection and was remarkably prolonged over 4 h. 2. The development of pyrogenic tolerance to IFN‐gamma was observed when rabbits were given I.V. injections on 3 successive days. Furthermore, the pyrogenicity of IFN‐gamma was significantly attenuated by heating at 60 degrees C for 40 min. The I.V. injection of IFN‐gamma enhanced the febrile response induced by endotoxin but had no effect on that induced by endogenous pyrogen. 3. The I.V. injection of a large dose of IFN‐gamma (6 x 10(6) units/kg) induced an acute phase response, which included a reduction in plasma concentration of iron and zinc. 4. The present results suggest that IFN‐gamma released from lymphocytes is one of the endogenous mediator proteins responsible for producing fever and acute phase response.