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Actions of neuropeptide Y on innervated and denervated rat tail arteries.
Author(s) -
Neild T O
Publication year - 1987
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.1987.sp016519
Subject(s) - contraction (grammar) , neuropeptide y receptor , excitatory postsynaptic potential , medicine , endocrinology , neuropeptide , depolarization , muscle contraction , neurotransmitter , chemistry , smooth muscle , biology , receptor , inhibitory postsynaptic potential , central nervous system
1. Neuropeptide Y caused a dose‐dependent contraction and depolarization of the smooth muscle of the rat tail artery. 2. 30 nM‐neuropeptide Y increased the contraction caused by either nerve‐released noradrenaline or smooth muscle action potentials. 3. 30 nM‐neuropeptide Y did not change the amplitude or rate of rise of the smooth muscle action potential. It did not change the amplitude of small excitatory junction potentials, suggesting that it did not affect neurotransmitter release. 4. 30 nM‐neuropeptide Y increased the contraction caused by exogenous noradrenaline, 5‐hydroxytryptamine and K in concentrations that gave submaximal contractions. It did not affect the response to higher concentrations that gave maximal or near‐maximal contractions.